CAN BOTOX BEAT THE BLUES?
Bern, Switzerland
Treating Depression with Botulinum toxin
Recently, studies demonstrated that persons suffering from depression benefited from a one-time botulinum toxin A (BTA) injection in the forehead.
However, these studies are unable to answer the question of how BTA exerts its antidepressant effect. Thus project seeks to unravel the mechanism(s) behind the effect in order to establish efficacy and safety for therapeutic applications.
-


Episode 1 - Protection and Application of Data
So who’s data is it anyway? Jacqueline and Alexandre was to know what happens to the data if a participant in the trial decides not to continue…

Episode 2 - Enlightened Consent
How long is too long? Jacqueline wants to know how do you go about ensuring participants in this trial really do give their “enlightened consent”?

Episode 3 - A Question of Ethics
Getting it right. Kristina emphasises the importance of ethics in scientific research…

Episode 5 - PLEX First Impressions - Alexandre
No navel gazing here. Alexandre is pleasantly surprised by the scope of the ethics consultation…

Episode 6 - PLEX First Impressions - Jacqueline
What happens next? Jacqueline reflects on the lack of feedback or continuity in scientific trials…

Episode 1 - How Long Are These Interviews ?
Caroline and Alexandre have their doubts about the time available for the interviews and what can be achieved in the time given.

Episode 2 - What Indicates Improvement in Depression?
The BERN group lay down some markers for when things “get better”...

Episode 1 - The Role of PLEX In This Research
The Bern group discusses potential scenarios for collaboration - with on eye on the funding issue...

Episode 2 - Depression & Fatigue
Alexandre explains how depression can undermine resistance to stress and fatigue...

Episode 3 - How Seasons Impact Illness
Spring or Autumn? Alexandre unpacks the complex impact that seasonal change can have on those suffering with bi-polar or depression...

Episode 4 - Decisive Diagnosis - Bipolor or Borderline Personality Disorder
Bipolar or borderline? Alexandre tells us why clarity in diagnosis is crucial...

Episode 5 - Is There A Lag Between Lab & Clinic?
"Bench to Bed" is a phrase frequently used to describe an idealised relationship between research and clinical practice - Kristine explains to the PLEX-RPs one reason why this process isn’t quite as simple as it sounds...

Episode 6 - How Useful Is A Diagnosis?
Is diagnosis and subsequent labelling a help or hindrance to people living with mental illness? Kristina touches on the potential for rejection sensitive dysphoria (RSD) in people with severe depression while Alexandre adds n since to the debate...

Research partners - botox project
-
Gregor
PI - Instigator of the MAPS Protocol and SYNERGIES/MAPS Project
-
Alexandre
Person with Live Experience (PLEX - RP)
-
Kristina
PI
view Other SYNERGIES projects
-
Making sense of senses
-
epigenetics of trauma
-
r.t.m.s.
-
G.L.A.D.
-
m.a.p.s