THE EPIGENETICS OF TRAUMA
Zurich, Switzerland
Seeking Novel Markers For Diagnostics and Treatment Response
Trauma-induced disorders are usually marked in individuals directly exposed but strikingly, they can also affect their offspring sometimes across generations.
This project, at the frontier between epigenetics and molecular psychiatry, aims to study how childhood trauma can influence mental and physical health across generations.
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Episode 1 - From Purgatory To Paradise
Cutting edge research needs money - Isabelle and her PLEX Research Partners discuss the often fruitless task of finding the funds…

Episode 2 - There Really Is A Biological Basis
On the track of trauma - and Renaud begins to feel the impact of SYNERGIES…

Episode 3 - De-mystification
Isabelle dispels rumours of a “double life” which leads to an exchange around a haunting professional dilemma…

Episode 4 - Useful and Constructive
Isabelle reveals the advantages participating in SYNERGIES and Cecilia evokes the problems she has with taking her medication…




Episode 1 - What Is Trauma?
Isabelle digs deep in an effort to explain what trauma means to her, with a little help from her PLEX Research Partners of course…

Episode 2 - Humiliation and How Destructive It Is
What shape can trauma take? Isabelle Mansuy’s group touch upon the impact of childhood humiliation...

Episode 3 - The Impact of SYNERGIES
Isabelle Mansuy begins a discussion around how SYNERGIES has altered her world view and what this implies for the future of her research...

Episode 4 - Why Me?
Cecile attempts to address the injustice of mental illness when she asks "why me?"

Episode 5- Does This Make You Angry?
Cecilia and Renaud reveal how they deal with anger and how acceptance rather than forgiveness is the more likely the solution...

Episode 6 - The Physical Legacy of Trauma
Trauma - never mind the mind, trauma leaves scars everywhere in the body...

Episode 7 - Why Use Mice For These Experiments?
Epigenetics or just plain old genetic variability? Tracking changes in DNA means you need to start with a level playing field and Isabelle explains why mice are the model subject...

?? CHECK IF THIS IS RIGHT FILE ON YOUTUBE? ZURICH SYNERGIES - LOCKDOWN 05
What do we mean when we talk about “trauma”? Isabelle and her PLEX-RPs take another shot at defining the phenomenon at the heart of her research - without which, a deeper understanding of the scientific and clinical ramifications are difficult to determine...

Episode 2 - Dealing With Mental Fallout of Trauma
What happens once you realise you have suffered severe childhood trauma? Cecilia reveals a bilateral approach to being bipolar...

Episode 3 - The Need to Network
Psychiatrists vs Psychologists - Cecilia and Hasna discuss the importance of having these two professions work in close collaboration when seeking a balanced approach to treating PLEX

Episode 4 - What Triggered Memory Of Trauma?
What happens when something hitherto forgotten comes back and unleashes emotional and psychological chaos? Cecilia begins to unravel the source of her issues and comes to a conclusion that couples courage with resolution...

Episode 5 - Being Labelled "Sick"
You want to know how being labelled as "mentally ill” can in and of itself destroy a life? Listen to Renaud as he so eloquently elucidates the semantic pitfalls and complex layers of guilt, stigma and hopelessness associated with coming

Episode 6 - Ideas for future collaboration...
Now that the Zurich SYNERGIES programme has attained cruising speed, Isabelle and the PLEX-RPs start to explore the possibility of other types of collaboration with a view to future publication...

Episode 1 - Is Research Funding Founded On Fads?
Funding for research is a tough nut to crack, especially when you are up against projects which appeal to established parameters or have "preordained" high-profile objectives. Isabelle laments the paucity of financing available to 'lean, mean and provocative" projects that

Episode 2 - Research - A woman's perspective...
When asked about how a career in science is affected by gender, Isabelle Mansuy relates a number of anecdotes that illustrate the prejudices still affecting women's education...

Episode 3
GRAAP (Associative and psychiatric Action Group) - an institution of interested individuals -Isabelle is curious about the organisation behind her PLEX Research Partners and the group obliges with a detailed expose...

Episode 4 - Laurence & the AFAAP
Laurence talks about her involvement with the support group for PLEX based in Fribourg

Episode 5 - Is Epigenetic Change Reversible?
Laurence talks about her involvement with the support group for PLEX based in Fribourg

Episode 6 - Living With Mental Illness Is A Full-time Job
Isabelle listens carefully as the PLEX-RPs build a picture of mental illness that steals your existence and is all consuming...

Episode 1 - Lockdown
Isabelle Mansuy shares her own "lockdown routine" during the first month of the COVID-19 pandemic...

Episode 2 - Lockdown
Jacqueline looks back 10 years and compares the current pandemic with her mental state then

Episode 3 - Lockdown
Isabelle explains how being in lockdown led her team to a new scientific discovery...

Episode 4 - Lockdown
Isabelle introduces the “Early Cause” consortium while experiments carried out during lockdown find a link between cardiovascular disease and trans-generational trauma...

Episode 5 - Lockdown
When things go wrong in childhood, it isn’t just the child who suffers. Isabelle offers some hope and scientific evidence of how this deeply disturbing reality might be avoided...

Episode 6 - Lockdown
How does childhood trauma launch us towards psychiatric issues later in life? Laurence alludes to her own experience and fingers “hypersensitivity” as the culprit...
Research partners - neuro-epigenetics project
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Prof. Isabelle mansuy
University Professor - Zurich
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Hasna
Person with Live Experience (PLEX - RP)
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Ceclia
Person with Lived Experience (PLEX - RP)
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Renaud
Person with Lived Experience (PLEX - RP)
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